Lipocalin 2 drives neutrophilic inflammation in alcoholic liver disease
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چکیده
منابع مشابه
Oxidative Stress and Inflammation: Essential Partners in Alcoholic Liver Disease
Alcoholic liver disease (ALD) is a multifaceted disease that is characterized by hepatic steatosis or fat deposition and hepatitis or inflammation. Over the past decade, multiple lines of evidence have emerged on the mechanisms associated with ALD. The key mechanisms identified so far are sensitization to gut-derived endotoxin/lipopolysaccharide resulting in proinflammatory cytokine production ...
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The intake of excess dietary fructose most often leads to non-alcoholic fatty liver disease (NAFLD). Fructose is metabolized mainly in the liver and its chronic consumption results in lipogenic gene expression in this organ. However, precisely how fructose is involved in NAFLD progression is still not fully understood, limiting therapy. Lipocalin-2 (LCN2) is a small secreted transport protein t...
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ژورنال
عنوان ژورنال: Journal of Hepatology
سال: 2016
ISSN: 0168-8278
DOI: 10.1016/j.jhep.2015.11.037